性别: 女
职称: 副教授 硕士生导师
最高学历、学位: 博士
毕业院校: 浙江大学
从事专业: 动物营养与饲料科学
联系电话: 18602757956
E-mail: canxiaok@126.com
研究方向
1.动物营养与免疫;
2.肠道微生物;
3.新型饲料添加剂的开发与应用
科研项目
1.国家自然科学基金青年项目,31802070,土壤对仔猪肠道菌群平衡及肠黏膜上皮屏障的影响及其调控机理,2019/01-2021/12,25万元,结题,主持。
2.武汉市知识创新专项,2022020801020394,哺乳期接触土壤对早期断奶仔猪肠道真菌菌群发育的影响及其机制研究,2022/06-2024/06,10万元,在研,主持.
3.动物营养与饲料科学湖北省重点实验室开放课题, 201906,森林土对断奶仔猪肠道菌群和屏障功能的影响及其机理研究, 2019/07-2020/12,4万元,结题,主持。
4.国家自然科学基金面上项目,32272906,SETDB1调节免疫应激诱导的仔猪肠上皮细胞程序性坏死的表观遗传机制及营养调控,2023/01-2026/12,54万元,在研,参与。
5.国家重点研发计划专项“十四五”任务,2022YFD1300403,畜禽新品种培育与现代牧场科技创新,2023.01-2026.12,440万元,在研,参与。
6.湖北省自然科学基金创新群体项目,2019CFA015,细胞死亡与猪肠道疾病的关系及其营养调控,2019/06-2021/06,50万,结题,参与。
7.武汉市应用基础前沿项目,2018020401011304,细胞程序性坏死在致病性大肠杆菌引起的仔猪肠炎中的作用及其营养调控,2018/07-2020/12,50万,结题,参与。
代表性论文
(1)Xiao K(#), Zhou MH, Lv QQ, He PW, Qin X, Wang D, Zhao JC, Liu YL (*). Protocatechuic acid and quercetin attenuate ETEC caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways. Journal of Animal Science and Biotechnology,2023,14:5.
(2)Xiao K(#), Yang Y, Zhang Y, Lv QQ, Huang FF, Wang D, Zhao JC, Liu YL(*). Long-chain PUFA ameliorate ETEC-induced intestinal inflammation and cell injury by modulating pyroptosis and necroptosis signaling pathways in IPEC-1 cells. British Journal of Nutrition. 2021,12(7):1-16
(3)Xiao K(#), Liu CC, Qin Q, Zhang Y, Wang XY, Zhang J, Odle J, Lin X, Hu CA, Liu YL(*). EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway. The FASEB Journal. 2020,34(2):2483-2496.
(4)Xiao K(#), Liu CC(#), Tu ZX,Xu Q, Chen SK, Zhang Y,Wang XY, Zhang J,Hu CAA, Liu YL(*). Activation of the NF-κB and MAPK signaling pathways contributes to the inflammatory responses, but not cell injury, in IPEC-1 cells challenged with hydrogen peroxide. Oxidative Medicine and Cellular Longevity. 2020,2020:5803639.
(5)Kan Xiao(#), Qiao Xu, Congcong Liu, Pengwei He, Qin Qin, Huiling Zhu, Jing Zhang, Ashley Gin, Guolong Zhang, Yulan Liu(*),Docosahexaenoic acid alleviates cell injury and improves barrier function by suppressing necroptosis signaling in TNF-α-challenged porcine intestinal epithelial cells. Innate Immunity. 2020,26(8):653-665.
(6)Xiao K(#),Jiao LF,Cao ST,Song ZH,Hu CH(*),Han XY(*),Whey protein concentrate enhances intestinal integrity and influences TGF-β1 and MAPK signaling pathways in piglets after lipopolysaccharide challenge, British Journal of Nutrition,2016,115(6):984-993.
(7)Xiao K(#),Song ZH,Jiao LF,Ke YL,Hu CH(*),Developmental changes of TGF-β1 and Smads signaling pathway in intestinal adaption of weaned pigs,PLoS ONE,2014,9(8): e104589.
(8)Xiao K(#),Cao ST,Jiao LF,Lin FH,Wang L,Hu CH(*),Anemonin improves intestinal barrier restoration and influences TGF-β1 and EGFR signaling pathway in lipopolysaccharide-challenged piglets,Innate Immunity,2016,22(5): 344-352.
(9)Xiao K(#),Cao ST,Jiao LF,Song ZH,Lu JJ,Hu CH(*),Transforming growth factor-β1 protects intestinal integrity and influences Smads and MAPK signal pathways in IPEC-J2 after tumor necrosis factor-α challenge,Innate Immunity,2017,23(3): 276-284.
(10)徐桥,王树辉,陈少魁,王秀英,肖勘(*),刘玉兰,以LPS构建IPEC1细胞损伤模型及相关指标的测定.中国畜牧杂志. 2020.8:140-145.
(11)黄菲菲,张阳,汪洋,李先根,王秀英,朱惠玲,刘玉兰,肖勘(*),脂多糖刺激后不同时间点断奶仔猪回肠和结肠中转化生长因子β1及Smads信号通路的动态变化.中国畜牧杂志. 2020.12:104-108.
(12)肖勘(#),涂治骁,黄菲菲,吕青青,朱惠玲,刘玉兰(*),细胞因子信号传导抑制因子1在双氧水诱导的IPEC-1细胞炎症和损伤中的作用.中国畜牧杂志.2021.8:80-84.
(13)秦旭,周墨涵,尉心田,陈少魁,刘玉兰,肖勘(*),脂多糖刺激后不同时间点断奶仔猪肠道中凋亡和自噬信号通路的动态变化.动物营养学报. 2023. 35:1513-1519