性别：男
最高学位、学历：博士研究生
毕业院校：澳门大学
从事专业：动物营养与饲料科学
联系电话: 19308429853
E-mail: loveskchen@163.com
研究方向
1.先天性免疫（巨噬细胞的功能调节）和获得性免疫（T细胞的功能调节）
2.免疫代谢重编程
3.开发针对畜禽免疫应激新型免疫疗法和营养干预手段
代表性论文
1.Shaokui Chen, Ruixin Li, Yibo Chen, Chon-Kit Chou,Zhexuan Zhang, Yang Yang, Ping Liao,Qingqing Wang, and Xin Chen.Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4+Foxp3+regulatory T cells. Biomedicine & Pharmacotherapy, 2022; 151: 113187. doi: 10.1016/j.biopha.2022.113187. (IF: 7.419)
2.Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen.Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4+Foxp3+Regulatory T Cells and Alleviates Imiquimod-Induced Psoriasis in Mice. Front Immunol. 2022; 13: 800283. doi: 10.3389/fimmu.2022.800283. (IF: 8.786)
3.Shaokui Chen, Zibei Lin, Long Xi, Ying Zheng, Qiong Zhou, Xin Chen. Differential role of TNFR1 and TNFR2 in the development of imiquimod-induced mouse psoriasis. J Leukoc Biol. 2021; 110(6): 1047-1055. doi: 10.1002/JLB.2MA0121-082R. (IF: 6.011)
4.Shaokui Chen, Yulan Liu, Xiuying Wang, Haibo Wang, Shuang Li, Haifeng Shi, Huiling Zhu, Jing Zhang, Dingan Pi, Chien-An Andy Hu, Xi Lin, Jack Odle. Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge. Innate Immun. 2016; 22: 577-587. doi: 10.1177/1753425916664124. (IF: 4.273)
5.Tianzhen He, De Yang, Xiao-Qing Li, Mengmeng Jiang, Md Sahidul Islam,Shaokui Chen, Yibo Chen, Yang Yang, Chon-Kit Chou, Anna L Trivett, Joost J Oppenheim, Xin Chen. Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+regulatory T cells. Sci Adv. 2020; 6(40): eaba6584. doi: 10.1126/sciadv. aba6584. (IF: 14.957)
6.Tianzhen He, Shuoyang Liu,Shaokui Chen, Jingyi Ye, Xueqiang Wu, ZhaoxiangBian, Xin Chen. The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4 + Foxp3 + Regulatory T Cells. Front Immunol. 2018; 9: 1556. doi: 10.3389/fimmu.2018.01556. (IF: 8.786)
7.Zibei Lin, Long Xi,Shaokui Chen, Jinsong Tao, Yan Wang, Xin Chen, Ping Li, Zhenping Wang, YingZheng. Uptake and trafficking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model. Acta Pharm Sin B. 2021; 11(4): 1047-1055. doi: 10.1016/j.apsb.2020.11.008. (IF: 14.903)
8.Long Xi, Zibei Lin, Fen Qiu,Shaokui Chen, Ping Li, Xin Chen, Zhenping Wang, Ying Zheng. Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment. Acta Pharm Sin B. 2022; 12(1): 339-352. doi: 10.1016/j.apsb.2021.07.019. (IF: 14.903)
9.Xiao Xu,Shaokui Chen, Haibo Wang, Zhixiao Tu, Shuhui Wang, Xiuying Wang, Huiling Zhu, Chunwei Wang, Jiadong Zhu, Yulan Liu. Medium-chain TAG improve intestinal integrity by suppressing toll-like receptor 4, nucleotide-binding oligomerisation domain proteins and necroptosis signalling in weanling piglets challenged with lipopolysaccharide. Br J Nutr. 2018; 119(9): 1019-1028. doi: 10.1017/S000711451800003X. (IF: 4.125)
10.Lin Zhang, Xiuying Wang,Shaokui Chen, Shuhui Wang, Zhixiao Tu, Guolong Zhang, Huiling Zhu, Xiangen Li, JianglinXiong, Yulan Liu. Medium-Chain Triglycerides Attenuate Liver Injury in Lipopolysaccharide-Challenged Pigs by Inhibiting Necroptotic and Inflammatory Signaling Pathways. Int J Mol Sci. 2018; 19(11): 3697. doi: 10.3390/ijms19113697. (IF: 6.208)
11.Kan Xiao, Congcong Liu, Zhixiao Tu, Qiao Xu,Shaokui Chen, Yang Zhang, Xiuying Wang, Jing Zhang, Chien-An Andy Hu, Yulan Liu. Activation of the NF-κB and MAPK Signaling Pathways Contributes to the Inflammatory Responses, but Not Cell Injury, in IPEC-1 Cells Challenged with Hydrogen Peroxide. Oxid Med Cell Longev. 2020; 2020: 5803639. doi: 10.1155/2020/5803639. (IF: 7.310)
12.Huiling Zhu, Yulan Liu,Shaokui Chen, Xiuying Wang, Dingan Pi, Weibo Leng, Feng Chen, Jing Zhang, Ping Kang. Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing hormone/corticotropin-releasing hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge. Br J Nutr. 2016; 115(11): 1947-57. doi: 10.1017/S0007114516001100. (IF: 4.125)
13.Yulan Liu, Xiuying Wang, Huanting Wu,Shaokui Chen, Huiling Zhu, Jing Zhang, Yongqing Hou, Chien-An Andy Hu, Guolong Zhang. Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS. Am J PhysiolRegulIntegr Comp Physiol. 2016; 311(2): R365-73. doi: 10.1152/ajpregu.00043.2016. (IF: 3.619)
14.陈少魁，刘玉兰，李权，等。脂多糖刺激对仔猪下丘脑-垂体肾上腺轴TLR4信号通路关键基因表达的影响,动物营养学报. 2014, 26(11): 3356-3361.
15.陈少魁，刘玉兰，李权，等。亚麻籽油对脂多糖刺激仔猪肝脏TLR4和NOD信号通路关键基因表达的影响,动物营养学报. 2016, 28(3): 891-898.
发明专利
1.Xin Chen, Ruixin Li,Shaokui Chen. Use of scutellarin in a medicament and a modulator for preventing or treating diseases, medicament, and modulator. United States Utility, UMPT175-2018, Granted.
